Doctor Lee Han Chung
Laboratory Director (Molecular Division) at Precision Diagnostics
BSc in Biotechnology, MSc in Medical Science, PhD in Neuroscience
Doctor Lee Han Chung is a Molecular and Cellular Biologist. He received his Bachelor of Science in Biotechnology from Universiti Putra Malaysia (UPM) in 2005. With a passion for science and medical research, he continued his journey. He joined a research team in the Pathology Department at Universiti Kebangsaan Malaysia (UKM) Medical Centre, where he obtained his Master’s degree in Medical Science. He studied the association of inherited mutations in the BRCA1 and BRCA2 genes with high-risk breast cancer patients, particularly in patients diagnosed with breast cancer at a younger age or with any familial history of breast and ovarian cancer.
By integrating genetic information identified during his research with the known prevalence of BRCA1 and BRCA2 mutation in Malaysian Breast Cancer patients thereby allowing for better management of cancer patients. oving forward, he joined the Medical Genetics Laboratory at UPM to pursue his PhD which focuses on the altered signaling pathway leading to an imbalance number of neurons and glial cells by using the brain of the mouse model with Down Syndrome (DS). With the research output, it may lead to therapeutics that can improve the quality of life of individuals with DS
Before joining Precision Diagnostics, Dr Lee is one of the members responsible for setting up research laboratories in a few Private universities, in addition to being a regulatory affairs personnel in a pharmaceutical company as well. He was the instructor and application specialist for molecular biology techniques in a private university and a life-science company, respectively.
Professional Qualifications
- Laboratory Director (Molecular) | Precision Diagnostics (PD)
- Assistant Treasurer | Precision Medicine & Scientific Wellness (PMedS) Association
- Regulatory Affairs Manager | Solution Biologics
- Scientist | Pantai Premier Pathology
- Laboratory Officer | Xiamen University Malaysia
- Graduate Student, PhD | Universiti Putra Malaysia
- Field Application Specialist | ScienceVision
- The IBRO International Travel Grants Award for attending the 39th Annual Meeting of the Japan Neuroscience Society, Yokohama, Japan, associated with Universiti Putra Malaysia (UPM)
- The IBRO-APRC Associate School of Neuroscience Award (International) for attending the Associate School of Neuroscience at the Faculty of Medical Science & Graduate School, Naresuan University, Phitsanulok, Thailand, associated with Universiti Putra Malaysia (UPM)
Dr Lee is well-trained in molecular experimental designs, Next-Generation Sequencing (NGS), quantitative PCR, and cell-based techniques. His current interest is using genetic testing to tailor medical treatments to individual patients with different disease conditions.
Publications
- A three-dimensional collagen construct to model lipopolysaccharide-induced activation of BV2 microglia, J Neuroinflammation 2016; 11(1):134
- Deciphering the secret role of Sox4 gene locus during mouse cerebral corticogenesis, Journal of Neurochemistry, 2014; 130 (Suppl. s1)
- Functional transcriptome analysis of the postnatal brain of the Ts1Cje mouse model for Down syndrome reveals global disruption of interferon-related molecular networks, BMC Genomics 2014; 15:624
- Identification of Novel Large Genomic Rearrangements at the BRCA1 Locus in Malaysian Women with Breast Cancer, Cancer Epidemiology 2010; 34(4): 442-447
- In depth analysis of the Sox4 gene locus that consist of sense and natural antisense transcripts, Data Brief 2016; 7:282-90
- In vitro generation of functional insulin-producing cells from lipoaspirated human adipose tissue-derived stem cells, Arch Med Res. 2012; 43(1):83-88
- Overexpressed interferon alpha or beta receptors in the brain of adult Ts1Cje mouse model of Down syndrome, Journal of Neurochemistry, 2014; 130 (Suppl. s1): 59-60
- Potential role of JAK-STAT signaling pathway in the neurogenic-to-gliogenic shift in Down syndrome brain, Neural Plasticity 2016: 7434191
- hTERT transfected human adipose-derived mesenchymal stem cells maintains adipogenic differentiation potential and expressed MSC markers, Medicine & Health 6, 2011; (1 Supplement). p. 258
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