Disclaimer Notice

a. This test is meant only for understanding your drug response based on your genetic makeup. The results presented on this report is offered as a supplementary drug information to assist physician/medical doctor in providing personalised medical treatment and recommendations for you. The results are as accurate as the information given on age, weight and ethnicity; additional of height, CYP2C9 enzyme inducer status and Amiodarone status for IWPC guided Warfarin Dosing.  The IWPC guided Warfarin Dosing Algorithm takes into account the following genotype: VKORC1(rs9923231) G/A, VKORC1(rs9923231) A/A, VKORC1(rs9923231) genotype unknown, CYP2C9 *1/*2, CYP2C9 *1/*3, CYP2C9 *2/*2, CYP2C9 *2/*3, CYP2C9 *3/*3 and CYP2C9 genotype unknown.  

b. The report is based on genetic variants curated by PharmGKB and publication that provides information on the impact of pharmacogenes on drug responses. The list of Tier 1 genetic variants that are detectable in the assay is outlined below, but is not limited to:  

ABCG2 rs2231142G,rs2231142T; CYP2C19 *1,*2,*3,*4.001, 4.002,*5,*6,*7,*8,*9,*10,*12,*13,*14,*15,*16,*17,*18,*19,*22,*23,*24,*25,*26,*28,*34,*35;CYP2C9 *1,*2,*3,*4,*5,*6,rs9332094C,*9,*10,*11,*12,*13,*15,*16,*17,*18,*19,*20,*21,*23,*24,*25,*26,*29,*30,*31,*32,*34,*36,*2+36,*38,*39,*40,*42,*43,*44,*45,*46,*47,*48,*49,*50,*51,*52,*53,*54,*55,*56,*57,*58;CYP2D6*1,*2,*4,*4.009,*4.010,*4.021,*6,*7,*8,*9,*10,*11,*14,*15,*17,*18,*22,*23,*25,*28,*29,*31,*33,*34,*35,*35+R365H,*40,*42,*45,*49,*51,*53,*54,*55,*56.001,*56.002,*62,*70,*71,*73,*75,*84,*86,*88,*95,*100,*103,*107,*109,*114,*139,*142,*154,*164,*171,*5;CYP3A4*1,*2,*3,*4,*5,*6,*7,*8,*9,*10,*11,*12,*13,*14,*15,*16,*17,*18,*19,*20,*22,*23, *37,*38; CYP3A5 *1,*3,*6,*7,*8; CYP4F2 *1,*2,*3,*4,*6; DPYD c.=,c.61C>T,c.295_298delTCAT,c.557A>G,c.703C>T,c.1129-5923C>G,HapB3,c.1156G>T,c.1679T>G,c.1898delC,c.1905+1G>A,c.2846A>T,c.2983G>T; G6PD B,A, Asahi,A-(202A_376G),Ube_Konan,Viangchan,Mira_d_Aire,Canton,202A_376G_1264G,Sinnai,Lages,Gaohe,Honiara,Sunderland,Rignano,Orissa,Aures,Kambos,Kozukata,Kamogawa,Palestrina,Metaponto,Costanzo,Amsterdam,Amazonia,Pro62Arg,Musashino,Songklanagarind,Hechi,Namouru,Murcia_Oristano,Swansea,Val77Leu,Lagosanto,Guangzhou,Urayasu,Vancouver,Hammersmith,Sao_Borja,Bao_Loc,Crispim,Acrokorinthos,Santa_Maria,Ananindeua,A-(680T_376G),A-(968C_376G), Mt_Sinai,Vanua_Lava,Quing_Yan,Valladolid,Belem,Liuzhou,Ilesha,Shenzhen,Mahidol,Plymouth,Taipei,Toledo,Naone,Volendam,Nankang,Miaoli,Shinshu,Chikugo,Malaga,Tsukui,Mediterranean,Pedoplis-Ckaro,Coimbra_Shunde,Nilgiri,Santiago,Arg198Leu,Sibari,Minnesota,Cincinnati,Harilaou, Radlowo,Mexico_City,North_Dallas,Asahikawa,Nanning,Durham,Stonybrook,Wayne,Aveiro,Roubaix,Cleveland_Corum,Lille,Bangkok,Sugao,La_Jolla,Wexham,Thr279Pro,Haikou,Chinese-1,Mizushima,Piotrkow,Osaka,Montalbano,West_Virginia,Seoul,Omiya,Ludhiana,Kalyan-Kerala,Nara,Manhattan, Rehevot,Farroupilha,Insuli,Villeurbanne,Chatham,Fushan,Torun,Chinese-5,Partenope,Ierapetra,Iwatsuki,Serres,Loma_Linda,Tenri,Tondela,MontpellierCalvo_Mackenna,Riley,Olomouc,Tomah,Lynwood,Madrid,Iowa,Guadalajara,Beverly_Hills,Hartford,Praha,Krakow,Wisconsin,Nashville,Alhambra,Bari,Puerto_Limon,Anadia,Covao_do_Lobo,Clinic,Abeno,Utrecht,Suwalki,Riverside,Japan,Munich,Tokyo,Georgia,Surabaya,Sumare,Pawnee,Telti_Kobe,Santiago_de_Cuba,S_Antioco,Cassano,Hermoupolis,Harima,Union,Andalus,Figuera_da_Foz,Amiens,Cosenza,Bangkok_Noi,Nice,Flores,Arg463Gly,Kamiube,Kaiping,Neapolis,Split,Fukaya,Campinas,Buenos_Aires,Arakawa,Brighton,Null; NUDT15 *1,*3; SLCO1B1*1,*37,*2,*3,*4,*5,*6,*7,*8,*9,*11,*13,*14,*15,*16,*23,*24,*25,*26,*27,*28,*29,*30, 31, *32,*33,*41,*47; TPMT*1,*2,*3B,*3C,*3A,*3D,*4,*5,*6,*7,*8,*9,*10,*11,*12,*13,*14,*15,*16,*17,*18,*19,*20,*21,*23,*24,25,*26,*27,*28,*29,*30,*31,*33,*34,*35,*36,*37; UGT1A1*1,*6,*27,*28,*36,*80,*80+*28; VKORC1 c.=,c.-1639G>A,c.106G>T,c.196G>A,c.383T>G 

c. The test does not rule out that the patient may have a different phenotype than reported due to absence of a detectable gene variant. Inaccurate results may be due to interference from rare, unreported, unknown, unpublished gene variations.  

d. The information presented is intended for use by a physician, pharmacist or other healthcare professional to be considered as one of the guides to advise a patient on the use of prescription drugs and therapeutic choice. The test results are not meant to be regarded as the sole source of recommendation for the next course of treatment. The ordering physician/healthcare provider is responsible for the diagnosis and management of disease and best course of treatment for a patient based on the data provided. Adherence to guidelines does not necessarily assure a successful medical outcome. Please consult your healthcare provider for all medical advice. Results are dependent on adequate specimen collection and processing. The Service Provider will not be held liable for any direct, indirect, special, consequential, exemplary, punitive, or any other damages arising from the use of the information and/or service within this report. If you have any questions about this report or wish to speak with Global Precision Diagnostics , please contact us through our website.