PRECISE Onco⁺:
FOR personalized and safer cancer care

PRECISE Onco⁺ is a germline pharmacogenomic test that supports cancer treatment with lifelong genetic insights. Unlike somatic testing, which focuses on tumor-specific mutations, PRECISE Onco⁺ analyzes your inherited DNA to guide treatment decisions from the start and throughout every stage of the cancer journey.

Recommended by General Practitioners
Uncovers stable, inherited genetic markers that inform treatment decisions for a lifetime, not just one phase of care
Clinically accredited and recommended for precision treatment
Maximizes treatment effectiveness and optimizes safety

What Is Germline Pharmacogenomics

A germline pharmacogenomic test looks at the DNA you were born with, also known as your inherited genetic makeup, to understand how your body is likely to respond to certain medications.

In the context of cancer care, this test helps doctors know in advance:

Because your germline DNA doesn’t change over time, this test provides lifelong insights that can guide cancer treatment decisions not just once, but at every stage of your cancer journey and even beyond, for other health conditions.

Germline vs. Somatic Pharmacogenomics Test

CHARACTERISTICS	GERMLINE	SOMATIC
FOCUS	Inherited genes, stable across life	Tumor-specific mutations, varies as cancer evolves
PURPOSE	Guides systemic treatment, predict drug response and adverse drug reactions (ADRs)	Identifies mutations for targeted therapy
VALUE	Long-term insight for lifelong treatment planning	Snapshot of current tumor biology

Why Germline Pharmacogenomics Matters

Adverse drug reactions (ADRs) are a serious yet often underestimated complication in cancer treatment. Many of these reactions stem from inherited genetic variations that affect how a patient metabolizes or transports medications, which is not detectable through somatic (tumor) testing alone. In fact,

1 in 3 cancer patients experience serious side effects from treatment, often due to genetic differences in drug metabolism ¹ ².
95% of people carry at least one actionable gene variant that can impact drug response ³.
Leading authorities like CPIC and DPWG support PGx-based prescribing with guidelines for 100+ gene-drug interactions ⁴.
The FDA lists 130+ pharmacogenomic biomarkers, many tied to cancer drugs ⁵.

Benefits Of PRECISE Onco⁺

Improves drug safety: Identifies patients at risk of severe toxicity from drugs like fluoropyrimidines (e.g., 5-FU), irinotecan, tamoxifen, and others
Guides chemotherapy and supportive care: Informs safer use of medications including painkillers, antiemetics, anticoagulants, and psychiatric drugs commonly prescribed alongside cancer treatment
Optimizes treatment in multimorbid patients: Cancer patients often have coexisting conditions; germline testing helps manage drug-(medications) and drug-gene interactions safely
Reduces trial-and-error prescribing: Supports dose adjustments and drug selection based on how your genes impact drug metabolism (CYP2D6, DPYD, UGT1A1, etc.)

Guidelines from the Clinical Pharmacogenetics Implementation Consortium (CPIC) and Dutch Pharmacogenetics Working Group (DPWG) now support pre-treatment germline testing for several commonly used cancer drugs ⁵.

Who Is It For?

Whether newly diagnosed or undergoing ongoing treatment, PRECISE Onco⁺ is for patients and oncologists seeking greater precision, safety, and personalization in cancer care. It’s especially valuable for individuals with:

Complex medication plans

Multimorbid conditions

Risks of adverse drug reactions (ADRs)

Long-term treatment strategies

Why Choose PRECISE Onco⁺

Lifelong Germline Insights
Inherited genetic markers guide treatment decisions at every stage, not just one point in time.
Comprehensive Gene Coverage
Tests key gene-drug interactions backed by global guidelines, supporting treatment and comorbidity management.
Personalized Precision
Helps doctor select the right drug, dose, and reduce side effects for truly tailored care.
Globally Accredited & Trusted
> HSA-accredited for clinical use in targeted therapy
> ISO 13485:2016 certified (NQA, UKAS)
> Successfully passed CAP's EQA for PGx, ensuring test quality and consistency
Clinical Support Team
PGx-certified experts offer CME and hands-on support for seamless integration into practice

ONE DNA TEST. LIFELONG INSIGHTS.

BOOK AN APPOINTMENT TODAY!

Personalize your medication, minimize side effects, and optimize cancer treatment with PRECISE Onco⁺.

Book Now >

How PRECISE Onco⁺ Is Changing Lives

Click any of the following to find out more about how PRECISE Onco⁺ is making a difference.

Case Study A - Avoiding Chemotherapy Toxicity Before It Starts

A 62-year-old woman was recently diagnosed with Stage II colon cancer and scheduled to begin a chemotherapy regimen that included 5-fluorouracil (5-FU). Before starting treatment, her oncologist recommended PRECISE Onco⁺ germline PGx testing to evaluate her risk for drug toxicity.

The test revealed that she had a DPYD gene variant, which meant her body would likely struggle to break down 5-FU, putting her at high risk for severe, potentially life-threatening side effects.

Thanks to this early insight, her treatment plan was adjusted:

> Her 5-FU dosage was significantly reduced based on CPIC guidelines

> She was closely monitored during the first cycle

As a result, she experienced mild and manageable side effects, completed her full chemotherapy course, and remained recurrence-free at her 12-month follow-up

Case Study B - Managing Mental Health Safely During Cancer Treatment

A 50-year-old breast cancer patient was struggling with anxiety, depression, and insomnia during her treatment journey. Her oncologist prescribed amitriptyline, a tricyclic antidepressant, to help her sleep and manage symptoms—but she quickly experienced extreme fatigue and dizziness.

Using the PRECISE Onco⁺ germline PGx panel, her care team discovered that she was a poor CYP2D6 metabolizer, meaning her body processed amitriptyline too slowly, leading to excessive drug levels in her system.

Her doctors:

> Discontinued amitriptyline

> Switched her to sertraline, which was more compatible with her genetic profile

> Adjusted her antiemetic dose (ondansetron) and pain medication accordingly

With the new medications, her symptoms improved significantly without side effects, and she was able to complete her radiation therapy with minimal disruptions.

How To Get Started With Your PRECISE Onco⁺ Test

Step 1

Get Your Test Kit

Contact Precision Diagnostics or visit your nearest PRECISE Pharmacogenomics panel to obtain your test.

Step 2

Collect Your Sample

Choose the collection method between a buccal swab (self-administered) or a blood draw (requires an appointment) at a designated facility.

Step 3

Lab Analysis

Your sample is sent to the Precision Diagnostics' lab for genetic analysis.

Step 4

Receive Your Report

Get your personalized results in 4 to 6 weeks, you’ll receive an email and SMS notification once your report is available in our app, PreciseEHR

Step 5

Consult with an Expert

Book your complimentary one-on-one consultation with a healthcare professional to review your results.

PRECISE Doctor Panel

Get a personalized one-to-one consultation with our expert doctors to help you understand your Onco⁺ report

Assoc. Prof. Dr. Hoo Fan Kee

Dr. Nada Syazana Zulkufli

FREQUENTLY ASKED QUESTIONS

How is PRECISE Onco⁺ different from tumor (somatic) testing?

Somatic testing looks for mutations within the tumor itself to guide targeted therapies. PRECISE Onco⁺ analyzes your inherited DNA, which doesn’t change over time, to predict how your body responds to over 500 medications, including chemotherapy, supportive care drugs, and treatments for coexisting conditions.

Who should consider taking this test?

PRECISE Onco⁺ is suitable for:

Patients newly diagnosed with cancer
Patients currently undergoing cancer treatment
Cancer survivors who may need long-term medication management
Individuals with a family history of cancer and medication sensitivities

What kind of drugs does PRECISE Onco⁺ cover?

The test covers 1,000+ genes linked to how the body processes over 500 commonly prescribed medications, including:

Chemotherapy (e.g. 5-FU, irinotecan)
Hormonal therapies (e.g. tamoxifen)
Pain relief, anti-nausea, psychiatric meds
Drugs for heart disease, diabetes, and other comorbidities

Is this test clinically validated?

Yes. PRECISE Onco⁺ is:

Accredited by Singapore Health Sciences Authority (HAS) for clinical decision-making
Quality-assured under ISO 13485:2016 by National Quality Assurance (NQA) & United Kingdom Accreditation Service (UKAS)
Regularly validated under College of American Pathologists (CAP)’s External Quality Assessment (EQA) program

Do I need to retake the test in the future?

No. Germline genetic variants do not change over time, so PRECISE Onco⁺ is a once-in-a-lifetime test that provides lifelong value.

Is the test covered by insurance?

Coverage varies by provider. Please consult your insurance company or speak to our customer care team for billing options and reimbursement assistance.

More FAQs >

One DNA Test. Lifelong Medication Insights.