fbpx

PRECISE Pharmacogenomics

Improve Patient Outcomes with PRECISE PGx

Featuring

PRECISE Pharmacogenomics

Using Genome-wide technology, we can determine how genetic information affects your body’s response to medication through our DNA Test Kit. Our report supports clinicians in providing Clinical Recommendations and Personalized Targeted Treatments. Find out more about 1st Clinical Recommended Genome-wide Pharmacogenomics, PRECISE Pharmacogenomics!

  • Covers more than 1,000 genes & 500+ commonly prescribed medication
  • 20+ Therapeutics Areas
  • Clinical Accredited & Recommended
  • Maximise & Optimise Medication Effectiveness

BENEFITS OF PHARMACOGENOMICS (PGx)

Up to 99% of Patients

have at least one (1) actionable gene variant that predisposes them to increased drug metabolism risk ¹

7.6% Improvement

in medication adherence using Pharmacogenomics (PGx) testing to guide treatment ²

Save $$$ on Medication

especially when treatment regimens are not tailored to the individual, resulting in more expenses towards medications ³ ⁴

Reduced Medical 'Trial & Error'

Healthcare providers and mental health therapies utilising PGx-guided treatment ⁵

  1. Ji, Y., Skierka, J. M., Blommel, J. H., et al. (2016). Preemptive pharmacogenomic testing for precision medicine: A comprehensive analysis of five actionable pharmacogenomic genes using next-generation DNA sequencing and a customized CYP2D6 genotyping cascade. Journal of Molecular Diagnostics, 18(3), 438–445. https://doi.org/10.1016/j.jmoldx.2016.01.003
  2. Winner, J. G., Carhart, J. M., Altar, C. A., et al. (2015). Combinatorial pharmacogenomic guidance for psychiatric medications reduces overall pharmacy costs in a 1-year prospective evaluation. Current Medical Research and Opinion, 31(9), 1633–1643. https://doi.org/10.1185/03007995.2015.1063483
  3. Dong, O. M., Wheeler, S. B., Cruden, G., et al. (2020). Cost-effectiveness of multigene pharmacogenetic testing in patients with acute coronary syndrome after percutaneous coronary intervention. Value in Health, 23(1), 61–73. https://doi.org/10.1016/j.jval.2019.08.002
  4. Deenen, M. J., Meulendijks, D., Cats, A., et al. (2016). Upfront genotyping of DPYD*2A to individualize fluoropyrimidine therapy: A safety and cost analysis. Journal of Clinical Oncology, 34(3), 227–234. https://doi.org/10.1200/JCO.2015.63.1325
  5. Hall-Flavin, D. K., Winner, J. G., Allen, J. D., et al. (2013). Utility of integrated pharmacogenomic testing to support the treatment of major depressive disorder in a psychiatric outpatient setting. Pharmacogenetics and Genomics, 23(10), 535–548. https://doi.org/10.1097/FPC.0b013e3283649b9a
PRECISE Pharmacogenomics (PGx)
Accredited Status

Accredited by HSA for Clinical Recommendation of Targeted Treatment, with NQA (National Quality Assurance Limited) assessed and registered ISO13485:2016 accredited by UKAS

Reactive-PGx

Reactive Pharmacogenomics:
The test administered in response to treatment failure or Adverse Drug Reactions (ADRs) ¹

Pre-emptive PGx

Pre-emptive Pharmacogenomics:
The test is administered before disease or prescription, enabling critical personalised medication decisions, especially during an emergency ¹

PGx_Warning

Pharmacogenomic looks at how your genes affect and respond to drugs, optimising its SAFETY & EFFECTIVENESS and
it is also NOT a hereditary disease test

Encrypted_PGx

Personal information is encrypted for data privacy

Gene-Marker

~ 100,000 ADME Gene markers tested for > 500 mainstream drugs, to safeguard children to elderly medication

1. Huang Q, Liao Y, Yu T, et al. A retrospective analysis of preemptive pharmacogenomic testing in 22,918 individuals from China. J Clin Lab Anal. 2023 Mar 14:e24855

PRECISE Pharmacogenomics (PGx)

Adverse Drug Reactions is the 6ᵗʰ leading cause of death worldwide ¹ ²

Gene Variability

Pharmacogenomics is responsible for ~ 80% variability in genes associated with drug safety and efficacy ³

FDA Warning

Facilitate Pharmacogenomics test suggested FDA warning on drugs such as Codeine Sulfate, Clopidogrel & Rasburicase ⁴ ⁵

Physicians

~ 70% of Physicians modified drug or dosage using Pharmacogenomics testing to reduce Adverse Drug Reactions (ADRs) ⁶

ReduceADRs

Pharmacogenomic testing has proven to reduce Adverse Drug Reactions (ADRs) or Medication Side Effects significantly ⁷

Trial&Error

99.5% individual have at least one (1) gene variant drug that requires drug adjustment ⁸

  1. U.S. Food and Drug Administration. (2018, March 6). Preventable adverse drug reactions: A focus on drug interactions. U.S. Food and Drug Administration. https://www.fda.gov/drugs/drug-interactions-labeling/preventable-adverse-drug-reactions-focus-drug-interactions

  2. Montastruc, J.-L., Lafaurie, M., de Canecause, C., et al. (2021). Fatal adverse drug reactions: A worldwide perspective in the World Health Organization pharmacovigilance database. British Journal of Clinical Pharmacology, 87(11), 4334–4340. https://doi.org/10.1111/bcp.14855

  3. Cacabelos, R., Cacabelos, N., & Carril, J. C. (2019). The role of pharmacogenomics in adverse drug reactions. Expert Review of Clinical Pharmacology, 12(5), 407–442. https://doi.org/10.1080/17512433.2019.1601875

  4. U.S. Food and Drug Administration. (2017). Codeine sulfate tablets [Label]. U.S. Food and Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2021/022402s014lbl.pdf

  5. U.S. Food and Drug Administration. (2022). PLAVIX® (clopidogrel tablets) for oral use [Label]. U.S. Food and Drug Administration. https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/020839s078lbl.pdf

  6. Swen, J. J., van der Wouden, C. H., Manson, L. E., et al. (2023). A 12-gene pharmacogenetic panel to prevent adverse drug reactions: An open-label, multicentre, controlled, cluster-randomised crossover implementation study. The Lancet, 401(10374), 347–356. https://doi.org/10.1016/S0140-6736(23)00102-0

  7. Gallagher, J. (2022, March 29). Matching drugs to DNA is a ‘new era of medicine’. BBC News. https://www.bbc.com/news/health-60903839

  8. Royal College of Physicians & British Pharmacological Society. (2022). Personalised prescribing: Using pharmacogenomics to improve patient outcomes. London: RCP and BPS. https://www.rcp.ac.uk

How Pharmacogenomics Work

EXAMPLE

Clinical Recommendations based on FDA Black Box Codeine Warning

Ultra Rapid Metabolizer
Normal Metabolizer
Intermediate Metabolizer
Poor Metabolizer

Gene variation for cytochrome P450 2D6 (CYP2D6) enzyme is known to be responsible for metabolizing codeine and other drugs. Depending on the variations of the gene, one could be a Poor, Intermediate, Normal or Ultra-Rapid Metabolizer. For instance, if you happen to be a CYP2D6 Ultra-Rapid metabolizer, your body would convert 5x to 30x times more codeine into morphine than standard, resulting in severe ADRs ⁽¹⁻³⁾.

  1. He T, Lardieri AB, Morgan JA. Pharmacist and Pediatrician Knowledge of Codeine Use in Children. J Pediatr Pharmacol Ther. 2018;23(4):293-2972).
  2. Dean L, Kane M. Codeine Therapy and CYP2D6 Genotype. 2012 Sep 20 [Updated 2021 Mar 30]. In: Pratt M, Scott SA, Pirmohamed M, et al., editors. Medical Genetics Summaries [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2012-. Available from: https://www.ncbi.nlm.nih.gov/books/NBK100662/.
  3. Koren G, Cairns J, Chitayat D, Gaedigk A, Leeder SJ. Pharmacogenetics of morphone poisioning in a breastfed neonate of a codeine-prescribed mother. Lancet. 2006 Aug 19;368(9536):704.

awarded by

the malaysia book of records

Precision Diagnostics is awarded for the ‘Largest Clinical Accredited Genome-Wide Pharmacogenomics Campaign” since 2025 and ‘1ˢᵗ Clinical Recommended for Genome-Wide Pharmacogenomics” since 2023.

PRECISE PHARMACOGENOMICS (PGx)

Make An Appointment Today

Pharmacogenomics is the key to personalized medicine. By understanding how your genes affect your response to medications, our test helps ensure that you receive the most effective treatment with fewer side effects. Imagine being able to avoid the trial-and-error process of finding the right medication and instead, get it right the first time.

Book Appointment
Precise PGx and NGx report

Steps to test PRECISE Pharmacogenomics

How to kickstart your PGx test?
  1. Contact our Customer Service hotline (+6011 1088 6581) to schedule an appointment to perform either a blood sample collection (physical) or a buccal swab (delivery)
  2. Save and remember the date and time of your appointment.
  3. Proceed with the set of instructions provided by our Customer Service agent.
  4. After performing your test (physical or delivery), do register yourself on the PreciseEHR app for validation purposes.
  5. Please wait for your results after four (4) to six (6) weeks, which will be available on the PreciseEHR app.
What is Pharmacogenomics (PGx)?

Pharmacogenomics (PGx), a core component in Precision Medicine, is the study of how genes affect a person’s response to medications. This field combines pharmacology (the science of drugs) and genomics (the study of genes and their functions) to develop effective, safe medications that can be prescribed based on a person’s genetic makeup while preventing medications’ side effects (known as Adverse Drug Reactions, ADRs). In other words, a medication can be safe for one but harmful for the other, even when prescribed with similar doses.

This test is open to the general public.
While there are no age restrictions for Pharmacogenomic (PGx) tests. For individuals below the age of 18, a legal guardian must complete the request and consent form. In the case of children, their phenotype (DNA traits) remains the same, but medication doses might change as they grow.

How to use DNA Collection Kit?

Click here and follow the instructions! Once finished, place the sample in the hazard bag and return to your respective PIC (person-in-charge).

Other options for receiving your PGx Test

 

  1. You can get it by contacting us at Precision Diagnostics or ask your nearest healthcare providers!
  2. Ensure that you received a consent form with details regarding the PRECISE Pharmacogenomics (PGx) test.
  3. Follow the instructions and proceed by handing your sample to your healthcare provider.
  4. Await for the report to generate after four (4) to six (6) weeks in the PreciseEHR app.

Your Health, Our Priority

In Malaysia, the rising prevalence of chronic diseases like diabetes, heart disease, and cancer is a growing concern. Many Malaysians are battling these severe conditions daily, often relying on medications that may not work optimally for everyone. But what if there was a way to tailor your treatment to your unique genetic makeup?

Frequently Asked Questions

At Precision Diagnostics, we are committed to empowering people globally with the knowledge they need to make informed decisions about their health. With our cutting-edge pharmacogenomics test, you can take control of your treatment and potentially prevent adverse drug reactions that could worsen your condition.

What is the difference of all tests?

DNA testing, or genetic testing, comes in many types – e.g. relationships, ancestry, cancers, medical diagnosis, etc. In general, genetic testing is a type of test that can identify changes in the genes, chromosomes or proteins in your body. Genetic testing takes a sample of either blood, skin, hair, tissue or amniotic fluid. Depending on the type of test, some tests may be able to confirm or rule out if you have a genetic condition. It may also help determine your chances of developing or passing on a genetic disorder (e.g. thalassemia).

On the other hand, Pharmacogenomics examines the relationship between an individual’s genetic makeup and their body’s response to medications. It investigates how genetic variations can influence the efficacy, safety, and metabolism of medications. With Pharmacogenomics, it can help healthcare professionals to personalise treatment plans, and optimise medication selection and dosage for patients. While it is not necessary to have both tests done together, what type of DNA tests you intend to do will give you different outcomes. When DNA tests are performed accurately, the test results may help to diagnose or uncover potential or the tendency to develop certain health condition(s) / disease(s). But when our PRECISE Pharmacogenomics (PGx) test is performed, it can help doctors choose the safest, most accurate and most effective drug, including dosage according to you, while minimising/preventing Adverse Drug Reactions (ADRs).

Preventive measures or treatment can be lifesaving, be it now or in the future.

Is PRECISE Pharmacogenomics reliable?

Our PRECISE Pharmacogenomics (PGx) reports provide access to genome-wide markers coverage of close to ~100,000 ADME markers and more than 1,000 genes, covering more than 500 commonly used drugs like pain-killer, antibiotics, diabetes, heart disease-related, cancer, etc. Most genetic tests in the market does not provide such comprehensive reports and they are only allowed to be used as references. Awarded as the “First Clinical Recommended Genome-Wide Pharmacogenomics” by The Malaysia Book of Records (MBR). Only healthcare professionals such as clinicians & medical doctors can refer to the PRECISE Pharmacogenomics (PGx) report and provide you with clinical recommendations, diagnosis, and personalised treatment plans alongside other clinical findings. However, this report DOES NOT replace your visit to a healthcare professional.

How accurate is PRECISE Pharmacogenomics?

With an analytical accuracy and reliability of over 99%, our genome-wide platform has proven to be highly precise and dependable. The clinical recommendations in our report are accredited by the Health Science Authority (HSA) of Singapore – HSA Class A Medical Device, NQA (National Quality Assurance Limited) accredited by UKAS (United Kingdom Accreditation Service) for ISO13485 certified; while our laboratory operations strictly adhere to the standards set by CAP and ISO 15189.

ATCC, known as Advancing Tomorrow’s Cure Community, is a community established to study how Asian genetics react to current medicines. To enjoy the sponsored pricing, it is REQUIRED to partake in the ATCC consent.

Your deidentified sample will be stored indefinitely as anonymous specimens for the option of being able to update your report at the minimal cost after the first FOC update with joining the ATCC, as well as for research purposes. Only an identification specimen number will be used, ensuring the anonymity and privacy of your data.
As for the possibility of research direction changes leading to activities related to cloning, Malaysia does not support human cloning therefore we will not be embarking on this area of research. Pharmacogenomics primarily focuses on understanding how an individual’s genetic makeup influences their response to drugs, optimising drug therapy based on genetic factors, and advancing personalized medicine. While research directions can evolve over time, the core focus of pharmacogenomics remains centered on drug response and genetic variability rather than cloning or genetic manipulation for other purposes.

AVAILABLE now

Precise EHR

Introducing PreciseEHR, the ultimate electronic health record (EHR) solution designed to revolutionise the way healthcare professionals manage patient data. Developed with the latest advancements in technology, PreciseEHR seamlessly integrates pharmacogenomics into daily clinical practice, ensuring personalized care and optimal treatment outcomes.

  • Comprehensive Reports
  • Intuitive Interface
  • Secure and Compliant
  • Real-time Updates
App Store
Google Play Store

doctor panel

Dr Nada, Laboratory Manager for Core Division at Precision Diagnostics

Dr. Nada Syazana Zulkufli

MBBS (Monash), MRCPI (Ireland), MPATH (Chemical)(UM), AM (Mal)

AP Dr Hoo Fan Kee, Board of Advisor at Precision Diagnostics

Assoc. Prof. Dr. Hoo Fan Kee

MD (Mal), MRCP (UK), MRCPS (Glasgow)

Testimonials

What Our Clients Say About Us

Precision Diagnostics is grateful for our patients’ or clients’ testimonies as our tests reflect on the trust and collaboration that we have built with our partners, whereby highlighting the value and impact of our service towards the community.