ADVANCING PRECISION IN CANCER CARE
Featuring
PRECISE Onco⁺
PRECISE Onco⁺ is a germline pharmacogenomic test that supports cancer treatment with lifelong genetic insights. Unlike somatic testing, which focuses on tumor-specific mutations, PRECISE Onco⁺ analyzes your inherited DNA to guide treatment decisions from the start and throughout every stage of the cancer journey.
- Recommended by General Practitioners
- Uncovers stable, inherited genetic markers that inform treatment decisions for a lifetime, not just one phase of care
- Clinically accredited and recommended for precision treatment
- Maximizes treatment effectiveness and optimizes safety
What Is Germline Pharmacogenomics (PGx)?
A germline pharmacogenomic (PGx) test looks at the DNA you were born with, also known as your inherited genetic makeup, to understand how your body is likely to respond to certain medications.
In the context of cancer care, this test helps doctors know in advance:
- Which drugs might work best for you
- What dosage is safest and most effective
- Whether you’re at risk of side effects from certain treatments
Because your germline DNA doesn’t change over time, this test provides lifelong insights that can guide cancer treatment decisions not just once, but at every stage of your cancer journey and even beyond, for other health conditions.
What's the difference?
Germline vs. Somatic Pharmacogenomics Test
| CHARACTERISTICS | GERMLINE PHARMACOGENOMICS TEST | SOMATIC PHARMACOGENOMICS TEST |
|---|---|---|
|
FOCUS |
Inherited genes, stable across life |
Tumor-specific mutations, varies as cancer evolves |
|
PURPOSE |
Guides systemic treatment, predict drug response and adverse drug reactions (ADRs) |
Identifies mutations for targeted therapy |
|
VALUE |
Long-term insight for lifelong treatment planning |
Snapshot of current tumor biology |
WHY GERMLINE PGx
Why Germline Pharmacogenomics Matters In Cancer Care?
Adverse drug reactions (ADRs) are a serious yet often underestimated complication in cancer treatment. Many of these reactions stem from inherited genetic variations that affect how a patient metabolizes or transports medications, which is not detectable through somatic (tumor) testing alone. In fact,
- 1 in 3 cancer patients experience serious side effects from treatment, often due to genetic differences in drug metabolism ¹ ².
- 95% of people carry at least one actionable gene variant that can impact drug response ³.
- Leading authorities like CPIC and DPWG support PGx-based prescribing with guidelines for 100+ gene-drug interactions ⁴.
- The FDA lists 130+ pharmacogenomic biomarkers, many tied to cancer drugs ⁵.
Benefits of PRECISE ONCO⁺
The Role Of PRECISE Onco⁺ In Safer, Smarter Cancer Care
- Improves drug safety: Identifies patients at risk of severe toxicity from drugs like fluoropyrimidines (e.g., 5-FU), irinotecan, tamoxifen, and others
- Guides chemotherapy and supportive care: Informs safer use of medications including painkillers, antiemetics, anticoagulants, and psychiatric drugs commonly prescribed alongside cancer treatment
- Optimizes treatment in multimorbid patients: Cancer patients often have coexisting conditions; germline testing helps manage drug-(medications) and drug-gene interactions safely
- Reduces trial-and-error prescribing: Supports dose adjustments and drug selection based on how your genes impact drug metabolism (CYP2D6, DPYD, UGT1A1, etc.)
Guidelines from the Clinical Pharmacogenetics Implementation Consortium (CPIC) and Dutch Pharmacogenetics Working Group (DPWG) now support pre-treatment germline testing for several commonly used cancer drugs ⁵.
Applicable for who
Who Is It For?
Whether newly diagnosed or undergoing ongoing treatment, PRECISE Onco⁺ is for patients and oncologists seeking greater precision, safety, and personalization in cancer care. It’s especially valuable for individuals with:
Complex medication plans
Multimorbid conditions
Risks of adverse drug reactions (ADRs)
Long-term treatment strategies
Why Choose PRECISE Onco⁺?
-
Lifelong Germline Insights
Inherited genetic markers guide treatment decisions at every stage, not just one point in time. -
Comprehensive Gene Coverage
Tests key gene-drug interactions backed by global guidelines, supporting treatment and comorbidity management. -
Personalized Precision
Helps doctor select the right drug, dose, and reduce side effects for truly tailored care. -
Globally Accredited & Trusted
> HSA-accredited for clinical use in targeted therapy
> ISO 13485:2016 certified (NQA, UKAS)
> Successfully passed CAP's EQA for PGx, ensuring test quality and consistency -
Clinical Support Team
PGx-certified experts offer CME and hands-on support for seamless integration into practice
PRECISE ONCO⁺
Book An Appointment Today!
Personalize your medication, minimize side effects, and optimize treatment with
PRECISE Onco⁺.
Real Stories, Real Impact
How PRECISE Onco⁺ Is Changing Lives
Click any of the following to find out more about how PRECISE Onco⁺ is making a difference.
Note: Please click on this image to view the case study details.
How to start?
How To Get Started with Your
PRECISE Onco⁺ Test
Get Your Test Kit
Contact Precision Diagnostics or visit your nearest PRECISE Pharmacogenomics panel to obtain your test.
Collect Your Sample
Choose the collection method between a buccal swab (self-administered) or a blood draw (requires an appointment) at a designated facility.
Lab Analysis
Your sample is sent to the Precision Diagnostics’ laboratory for processing.
Receive Your Report
Your results will be ready in 4 to 6 weeks. You’ll receive an email and SMS notification once your report is available in our app, PreciseEHR.
Consult with an Expert
Book your complimentary one-on-one consultation with a healthcare professional to review your results.
available now
Go Paperless With PreciseEHR
Take charge of your health with PreciseEHR, your secure electronic health record (EHR) platform. Access your Pharmacogenomics report, track your health data, and stay informed—all in one place.
- Comprehensive Reports — Get detailed, easy-to-interpret insights at your fingertips.
- Intuitive Interface — Navigate effortlessly for a smooth experience.
- Secure & Compliant — Keep your data protected with top-tier security.
- Real-time Updates — Stay informed with instant access to the latest reports.
- Easy Access — View your reports anytime, anywhere and accessible
one-to-one personalized consultation
PRECISE Pharmacogenomics
Doctor Panel
Get a personalized one-to-one consultation with our expert doctors to help you understand your pharmacogenomic report
Dr. Nada Syazana Zulkufli
MBBS (Monash), MRCPI (Ireland), MPATH (Chemical)(UM), AM (Mal)
Assoc. Prof. Dr. Hoo Fan Kee
MD (Mal), MRCP (UK), MRCPS (Glasgow)
Frequently Asked Questions
How is PRECISE Onco⁺ different from tumor (somatic) testing?
Somatic testing looks for mutations within the tumor itself to guide targeted therapies. PRECISE Onco⁺ analyzes your inherited DNA, which doesn’t change over time, to predict how your body responds to over 500 medications, including chemotherapy, supportive care drugs, and treatments for coexisting conditions.
Who should consider taking this test?
PRECISE Onco⁺ is suitable for:
- Patients newly diagnosed with cancer
- Patients currently undergoing cancer treatment
- Cancer survivors who may need long-term medication management
- Individuals with a family history of cancer and medication sensitivities
What kind of drugs does PRECISE Onco⁺ cover?
The test covers 1,000+ genes linked to how the body processes over 500 commonly prescribed medications, including:
- Chemotherapy (e.g. 5-FU, irinotecan)
- Hormonal therapies (e.g. tamoxifen)
- Pain relief, anti-nausea, psychiatric meds
- Drugs for heart disease, diabetes, and other comorbidities
Is this test clinically validated?
Yes. PRECISE Onco⁺ is:
- Accredited by Singapore Health Sciences Authority (HAS) for clinical decision-making
- Quality-assured under ISO 13485:2016 by National Quality Assurance (NQA) & United Kingdom Accreditation Service (UKAS)
- Regularly validated under College of American Pathologists (CAP)’s External Quality Assessment (EQA) program
Do I need to retake the test in the future?
No. Germline genetic variants do not change over time, so PRECISE Onco⁺ is a once-in-a-lifetime test that provides lifelong value.
Is the test covered by insurance?
Coverage varies by provider. Please consult your insurance company or speak to our customer care team for billing options and reimbursement assistance.
PRECISE ONCO⁺
Book An Appointment Today!
Personalize your medication, minimize side effects, and optimize treatment with
PRECISE Onco⁺.
References:
- Iwuchukwu, O. F., & Smith, L. H. (2022). “Pharmacogenomics of Cancer Therapy: Drug–Gene Interactions That Influence Treatment Toxicity and Efficacy.” Pharmacogenomics and Personalized Medicine, 15, 93–108.
- Dunnenberger, H. M. et al. (2015). “Preemptive clinical pharmacogenetics implementation: current programs in five US medical centers.” Annual Review of Pharmacology and Toxicology, 55, 89–106.
- Relling, M. V., & Klein, T. E. (2011). “CPIC: Clinical Pharmacogenetics Implementation Consortium of the Pharmacogenomics Research Network.” Clinical Pharmacology & Therapeutics, 89(3), 464–467.
- U.S. Food & Drug Administration (FDA). “Table of Pharmacogenomic Biomarkers in Drug Labeling.
- Bank PCD, Caudle KE, Swen JJ, Gammal RS, Whirl-Carrillo M, Klein TE, Relling MV, Guchelaar HJ. Comparison of the Guidelines of the Clinical Pharmacogenetics Implementation Consortium and the Dutch Pharmacogenetics Working Group. Clin Pharmacol Ther. 2018 Apr;103(4):599-618. doi: 10.1002/cpt.762. Epub 2017 Oct 10. PMID: 28994452; PMCID: PMC5723247.